Home » Research Products » Rapid human Cystatin C ELISA

Rapid human Cystatin C ELISA

Product Code: 31241
Cat. No.
Product
Assay range
Size
Price*
31241
Rapid Human Cystatin C ELISA
0.23 -30 ng/ml
96T/Kit
330.00 US$

 

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INTRODUCTION

Human cystatin c (or cystatin 3), which is composed of 120 amino acid residues, belongs to the cystatins superfamilly that inactivates lysosomal cysteine proteinases. As a strongly cationic and low-molecular weight (13.4 kDa) protein, it is almost freely filtered across the glomerular membrane, and is mainly used as a biomarker of kidney function. A growing body of evidence suggests that cystatin c is a more reliable biomarker of glomerular filtration rate than creatinine [1-3] . In addition to kidney disease, altered serum levels of cystatin c are associated with several types of cardiovascular disease, including myocardial infarction, stroke, heart failure, peripheral arterial disease and metabolic syndrome [4-7] . It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease [8, 9] . Furthermore, Cystatin c has also been investigated as a prognostic marker in several forms of cancer [11, 12] .

 

TYPICAL STANDARD CURVE

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

 

Human cystatin c standard curve (4-parameter)

 

ASSAY CHARACTERISTICS

 

A. Sensitivity:

The lowest level of human cystatin c that can be detected by this assay is 0.23 ng/ml.

 

B. Specificity:

The antibodies used in this assay are specific to human cystatin c and do not cross-react with mouse and rat cystatin c, and other cytokine or hormone molecules.

 

C. Precision:

 

Intra-assay Precision (Precision within an assay)

Three samples of known concentration were tested 12 times on one plate.

 

Inter-assay Precision (Precision between assays)

Three samples of known concentration were tested in 10 separate assays.

 

 D. Recovery:

Serum samples were spiked with different amounts of human cystatin c and assayed.

 

 

 

 

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5/F, Biotech Centre 2, No. 11 Science Park West Avenue,

Hong Kong Science Park, Shatin, N.T., Hong Kong

Email:

info@immunodiagnostics.com.hk      sales@immunodiagnostics.com.hk

Phone:

(+852) 3502 2780

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(+852)  3502 2781

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