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Human FGF-19 ELISA

Product Code: 31200

Cat. No.
Product
Assay range
Size
Price*
31200
Human FGF-19 Elisa kit
15.6-2000pg/ml
96T/Kit
400.00 US$

 

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INTRODUCTION

 

Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF-23, each member functions as an important regular of nutrient metabolism [1]. The primary source of endocrine FGF-19 is the ileum, bile acids release into the intestine after a meal to induce expression of FGF-19 [2]. Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis [3]. Several pharmacologic studies in hyperglycaemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol levels [4][5]. Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis [6].

 

TYPICAL STANDARD CURVE

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

 

Human FGF-19 standard (4-parameter)

 

ASSAY CHARACTERISTICS

 

A. Sensitivity:

The lowest level of FGF-19 that can be measured by this assay is 15.6 pg/ml.

 

B. Specificity:

The antibodies used in this assay are specific to human FGF-19 and do not cross-react with human Adiponectin, FGF-21, FABP4, LCN2, RBP4 and PAI-1.

 

C. Precision:

Intra-assay Precision (Precision within an assay) C.V< 4.5%.

Inter-assay Precision (Precision between assays) C.V< 5.6%.

 

Publications Citing Our Products:

 

 Zhang J, et al. Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose. Sci Rep. 2017; 7(1):6042.
 Fang, Qichen, et al. Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels. Diabetes Care. 2013; 36(9):2810-4.
 Hao, Yaping, et al. Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals. PLoS One. 2013; 8(8):e72345.

 

 

 

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Tags: FGF19