Home » Research Products » Human rentinol binding protein 4 (RBP4) ELISA

Human rentinol binding protein 4 (RBP4) ELISA

Product Code: 31060
Cat. No.
Product
Assay range
Size
Price
31060
Human RBP4 ELISA kit
1.56-200 ng/ml
96T/Kit
330.00 US$

 

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INTRODUCTION

Retinol binding protein 4(RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker1 . Serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes2,3. Animal experiments found that increased secretion of RBP4 might reduces insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2 . Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased highdensity lipoprotein cholesterol levels4 . Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis5 .

 

TYPICAL STANDARD CURVE

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

 

Human RBP4 standard curve (4-parameter)

 

ASSAY CHARACTERISTICS

 

A. Sensitivity:

The lowest level of RBP4 that can be detected by this assay is 1.56 ng/ml.

 

B. Specificity:

The antibody pair used in this assay is specific to human RBP4 and does not cross-react with mouse and rat RBP4, and other cytokine or hormone molecules.

 

C. Precision:

Intra-assay Precision (Precision within an assay)

Three samples of known concentration were tested 16 times on one plate.

 

Inter-assay Precision (Precision between assays)

Three samples of known concentration were tested in 10 separate assays.

 

D. Recovery:

Serum samples were spiked with different amounts of human RBP4 and assayed.

 

Publications Citing Our Products:

 

 Fang, Qichen, et al. Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels. Diabetes Care. 2013; 36(9):2810-4.
 Hao, Yaping, et al. Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals. PLoS One. 2013; 8(8):e72345.
 

 

 

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