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CRP protein [IVD Raw Materials]

Product Code: 41120-S10

 

Type:

Native

Cat. No.:

41120-S10

Tag:

N/A

Size:

1 mg

Source:

Human Fluids

Purity:

>98%

Other names:

CRP

Species:

Human

 

 

Description

 

Native protein purified from human fluids

Immunogen grade antigen for research use or manufacturing only.

 

 

Introduction to the Molecule

 

C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.1 It has long been recognized that CRP is closely related to immunology, inflammation and host defence, as a result it has been used as an inflammatory marker. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.2-4 Normally CRP is presenting only in a trace amount in circulation (<1 mg/ml)5-6 but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 mg/ml, 1-3 mg/ml and >3 mg/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.7 Therefore, blood CRP level has become a promising measure of CVD risk.8-9

 

Formulation

 

Solution in 0.1M Tris, 0.2M NaCl, 2mM CaCl2, 0.1% NaN3, PH:7.5

 

Storage

 

Less than 3 months: store at 4°C.

For long-term storage: aliquot and freeze at -20°C. Avoid repeated freeze/defrost cycles.

 

Applications

 

Standard ELISA test, Western blotting

 

Quality Control Test

 

BCA to determine quantity of the protein.

SDS-PAGE to determine purity of the protein.
 

 

Reference:

 

  1. Thompson D., Pepys M.B. and Wood S.P. (1999) Structure, 7, 169-177.

  2. Festa A, D’Agostino R. Jr., Tracy R.P. and Haffner S.M. (2002) Diabetes, 51, 1131-1137.

  3. Verma S. and Yeh E.T. (2003) Am J Physiol, 285, R1253-R1258.

  4. Jialal I., Devaraj S. and Venugopal S.K. (2004) Hypertension, 44, 6-11.

  5. Kindmark C.O. (1972) Scand J Clin Lab Invest, 29, 407-411.

  6. Macy E.M., Hayes T.E. and Tracy R.P. (1997) Clin Chem, 43, 52-58.

  7. Ridker P.M. (2004) Am Heart Hosp J, 2 (4 Suppl 1), 4-9.

  8. Benzaquen l.R., Yu H. and Rifai N. (2002) Crit Rev Clin Lab Sci, 39, 459-497.

  9. Pearson T.A. et al., (2003) Circulation, 107, 499-511.

 

 

 

 

Contact Us

 

Address:

 

5/F, Biotech Centre 2, No. 11 Science Park West Avenue, 

Hong Kong Science Park, Shatin, N.T., Hong Kong

Email: 

info@immunodiagnostics.com.hk      sales@immunodiagnostics.com.hk

Phone:

(+852) 3502 2780    

Fax:  

(+852)  3502 2781

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