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Human Proteinase 3 (PR3) ELISA

Human Proteinase 3 (PR3) ELISA
Product Code: 31300
Cat. No.
Product
Assay range
Size
Price*
31300
Human Proteinase 3 (PR3) ELISA
0.078 - 10 ng/ml
96T/Kit
400.00 US$

 

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INTRODUCTION

Proteinase 3 (PR3), also known as myeloblastin, Wegener autoantigen, PRTN3 and NP- 4, is one of the hematopoietic serine proteases localized in the primary granules of polymorphonuclear neutrophils (PMNs) 1,2 . The primary function of PR3 is recognized as to participate in direct intracellular killing of phagocytosed pathogens in phagolysosomes and degradation of extracellular matrix components at inflammatory sites 3 . PR3 has also been proven to be able to process some pro-inflammatory cytokines, such as IL- 1β, IL-18 and TNF-α, activate mitogen activated protein kinase (MAPK) signaling through proteinase activated receptor-1 (PAR1), and induce endothelial cell apoptosis through NF-κB signaling pathways 4,5 . PR3 is identified as the target autoantigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in Wegener granulomatosis 6 . Increased PR3 levels have been reported in patients with acute myocardial infarction 7 , and in subjects with type 1 diabetes 8 .

 

TYPICAL STANDARD CURVE

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

 

Human PR3 standard curve (4-parameter)

 

Publications Citing Our Products:

 

Wang, Yudong, et al. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes. 2014; 63(12):4239-48.
 

 

 

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