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Fatty-acid binding protein 4 (mouse), rabbit polyclonal antibody

Product Code: 12030
Cat. No.
Product
Application        
Size       
Price*
 12030
FABP4 (mouse), rabbit PAb
WB, IP
0.1 mg
200.00 US$

 

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Introduction

 

Fatty-acid binding protein 4(FABP4), also termed adipocyte fatty-acid binding protein(A-FABP), or aP2, is a novel adipocyte-expressed factor which accounted for ~6% of total cellular proteins. Several animal experiments suggested that FABP-4 plays a key role in the link between obesity and various features of metabolic syndrome. Mice with targeted disruption of FABP-4 accompany FABP-5 almost completely protect against diet-induced obesity, insulin resistance, dyslipidemia, type 2 diabetes, and fatty liver disease. Studies in human found FABP-4 serum levels were significantly increased in overweight and obese subjects, which predicted the risk to develop a metabolic syndrome and type 2 diabetes. Additionally, serum FABP-4 levels were associated with carotid atherosclerosis and coronary artery disease.

 

Isotype/Preparation:

Rabbit crude IgG was purified by protein-G column.

 

Immunogen:

Recombinant full-length Mouse FABP4 expressed in E.coli.

 

Specificity:

The antibody detects Mouse FABP4. Formulation: Solution in PBS.

 

Storage:

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

 

Application/Usage:

Western blot - This antibody can be used at 0.5 - 1 µg/mL with the appropriate secondary reagents to detect mouse FABP4.

Immunoprecipitation, ELISA and immunocytochemistry are not tested.

 

Reference:

[1] Xu A, et al. (2006) Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome. Clin Chem. 52(3):405-13.

[2] Xu A, et al. (2007) Circulating adipocyte–fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 115:1537–1543.

[3] Rhee EJ, et al. (2009) The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults. Eur J Endocrinol. 160(2):165-72.

 

 

 

 

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