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Rat C-peptide ELISA

Product Code: 33780
Cat. No.
Product
Assay range
Size
Price*
33780
Rat C-peptide Elisa kit
0.075 - 2.5 ng/ml
96T/Kit
400.00 US$

 

 

INTRODUCTION

 

Insulin is a kind of peptide hormone which is critical for glucose homeostasis. The mature Insulin peptide is derived from Proinsulin, which includes the Insulin A and B chains connected by a peptide fragment (C-peptide). Proinsulin is processed within the endoplasmic reticulum of pancreatic beta cells into equimolar ratios of mature Insulin and C-peptide. Mouse C-peptide 1 is a single chain peptide composed of 29 amino acids, while C-peptide 2 is composed of 31 residues. C-peptide is secreted together with insulin.

 

The role of C-peptide has been considered to keep the best configuration to form three disulfide bonds, and has no biological activity, however, recent studies indicated that C-peptide can bind, probably, a G-protein coupling specific receptor present on the surface of endothelial cells, kidney microtubule cells and fibroblasts, resulting in activation of calcium-dependent intracellular signaling, activation of Na+-K+-ATPase, and enhancement of NO synthesis. Administration of C-peptide to DM1 patients enhances blood circulation in the skeletal muscle and skin, and also minimizes kidney glomerular hyperfiltration, decreasing albumin excretion into urine, and also improves nervous function, indicating that C-peptide should be given together with insulin to DM1 patients. Important region to bind receptor has been reported to be C-terminal penta peptide 

 

TYPICAL STANDARD CURVE

 

The following standard curve is provided for demonstration only. A standard curve should be generated for each set of sample assay.

 

 

Rat C-peptide standard curve (4-parameter)

 

 

ASSAY CHARACTERISTICS

 

A. Sensitivity:

The lowest level of Rat C-peptide that can be detected by this assay is 0.15 ng/ml.

 

 

B. Precision:

Intra-assay Precision (Precision within an assay) C.V <10%.

Inter-assay Precision (Precision between assays) C.V <10%.

 

 

 

Contact Us

 

Address:

 

5/F, Biotech Centre 2, No. 11 Science Park West Avenue,

Hong Kong Science Park, Shatin, N.T., Hong Kong

Email:

info@immunodiagnostics.com.hk      sales@immunodiagnostics.com.hk

Phone:

(+852) 3502 2780

Fax:

(+852)  3502 2781

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