C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa.1 It has long been recognized that CRP is closely related to immunology, inflammation and host defence, as a result it has been used as an inflammatory marker. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.2-4 Normally CRP is presenting only in a trace amount in circulation (<1 mg/ml)5-6 but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 mg/ml, 1-3 mg/ml and >3 mg/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction.7 Therefore, blood CRP level has become a promising measure of CVD risk.8-9

 

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Rabbit IgG was purified by protein-G column

Native Human C- reactive Protein (CRP)

The antibody detects human CRP.

Solution in PBS.

Standard ELISA, Immunoturbidimetric assay

BCA to determine quantity of the antibody.

 

Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

1- Thompson D., Pepys M.B. and Wood S.P. (1999) Structure, 7, 169-177.

2- Festa A, D’Agostino R. Jr., Tracy R.P. and Haffner S.M. (2002) Diabetes, 51, 1131-1137.

3- Verma S. and Yeh E.T. (2003) Am J Physiol, 285, R1253-R1258.

4- Jialal I., Devaraj S. and Venugopal S.K. (2004) Hypertension, 44, 6-11.

5- Kindmark C.O. (1972) Scand J Clin Lab Invest, 29, 407-411.

6- Macy E.M., Hayes T.E. and Tracy R.P. (1997) Clin Chem, 43, 52-58.

7- Ridker P.M. (2004) Am Heart Hosp J, 2 (4 Suppl 1), 4-9.

8- Benzaquen l.R., Yu H. and Rifai N. (2002) Crit Rev Clin Lab Sci, 39, 459-497.

9- Pearson T.A. et al., (2003) Circulation, 107, 499-511.