Fibroblast growth factor 19 (FGF-19) is a member of a subfamily of FGFs that includes FGF-21 and FGF-23, each member functions as an important regulator of nutrient metabolism [1]. The primary source of endocrine FGF-19 is the ileum, bile acids release into the intestine after a meal to induce expression of FGF-19 [2]. Circulating FGF-19 plays an important role in maintaining proper bile acid homeostasis [3]. Several pharmacologic studies in hyperglycemic, obese animal models have shown that FGF-19 can improve metabolic rate and lower serum glucose and hepatic triglyceride and cholesterol levels [4,5]. Like insulin, FGF-19 functions as postprandial hormone to govern hepatic protein synthesis, glycogen synthesis and gluconeogenesis, but does not stimulate lipogenesis [6].

Recombinant full-length human FGF-19 expressed in E.coli.

The antibody detects circular human FGF-19.

Liquid in phosphate-buffered saline (PBS).

Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.

ELISA - the antibody can be used as capture and detection antibody in ELISA.

Antigen affinity-purified

[1] Beenken A, et al. (2009) Nat Rev Drug Discov; 8: 235– 253.

[2] Inagaki T, et al. (2005) Cell Metab; 2: 217– 225.

[3] Lundasen T, et al. (2006) J Inter Med;260:530-536.

[4] Tomlinston E, et al.  (2002) Endocrinology; 143: 1741-1747.

[5] Fu L, et al. (2004) Endocrinology; 145: 2594-2603.

[6] Kir S, et al. (2011) Science; 331: 1621– 1624.