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IFN-γ, Mouse

IFN-γ, Mouse

SKU: UA040065

★ Download Datasheet PDF ★

★ Download MSDS ★

 

 Species:

Mouse

Expression System:

E.coli

MW:

16 kDa (reducing)

Accession:

P01580

Cat No.

UA040065

Endotoxin:

1 EU/μg

Purity:

>95% as determined by SDS-PAGE

  • INTRODUCTION

    Interferon gamma (IFN-γ) is a cytokine critical to both innate and adaptive immunity, and functions as the primary activator of macrophages, in addition to stimulating natural killer cells and neutrophils. A non-IgE-mediated anaphylactic reaction and severe bronchospasm have been reported once after the first injection of interferon gamma. IFN-γ activates cells via a different
    receptor than IFN-α and IFN-β, which accounts for the different physiological properties of the
    proteins. Production of IFN-γ is largely restricted to activated CD4+ TH1 T cells, CD8+ T cells, and natural killer cells. One of the most important consequences of IFN-γ secretion is the activation of macrophages. In addition, IFN-γ plays a central role in inflammatory responses by activating endothelial cells, promoting TH1 cell development and cellular immune responses, and upregulation of major histocompatibility complex protein expression on antigen-presenting cells.

  • Amino Acid Sequence

    His23-Cys155
    HGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC

  • Physical Appearance:

    Lyophilized powder

  • Buffer

    20mM Tris, 200mM NaCl, pH8.0

  • Reconstitution

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • Stability and Storage

    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution.

    Note: Please avoid repeated freeze-thaw cycles

$999.00Price

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